Ovariectomy and 17 -Estradiol Replacement Do Not Alter -Amyloid Levels in Sheep Brain
نویسنده
چکیده
School of Psychiatry and Clinical Neurosciences (A.M.B., G.V., R.N.M.), The University of Western Australia, and Sir James McCusker Alzheimer’s Disease Research Unit (A.M.B., G.V., R.N.M.), School of Psychiatry and Clinical Neurosciences and University of Western Australia, Hollywood Private Hospital, Nedlands 6009, Australia; Centre of Excellence in Alzheimer’s Disease Research and Care (A.M.B., G.V., R.N.M.), Edith Cowan University, Joondalup 6027, Australia; and School of Veterinary and Biomedical Sciences (M.C.), Murdoch University, Perth, Western Australia 6105, Australia
منابع مشابه
Ovariectomy and 17beta-estradiol replacement do not alter beta-amyloid levels in sheep brain.
The benefits of estrogen replacement as a preventative treatment for Alzheimer's disease (AD) are subject to debate. Because the effects of estrogen depletion and replacement on accumulation of the neurotoxic beta-amyloid (A beta) peptide in transgenic animal models of AD have been variable, we examined A beta levels and oxidative stress in a nontransgenic animal model. Sheep have traditionally...
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The aim of this study was to examine the changes in serum cytokine levels (Il-1α, Il-6, TNF-α) in ovariectomized rats with and without replacement estrogen therapy. Female Wistar rats were used. Rats were qualified for the following groups: Cl control, SH sham-operated, OV after ovariectomy, OVH after ovariectomy receiving 17 β-estradiol in three different doses (1.25, 12.5, 125 μg) during seve...
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